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Target
17-beta-hydroxysteroid dehydrogenase type 3
Ligand
BDBM91713
Substrate
n/a
Meas. Tech.
ChEMBL_1510493 (CHEMBL3607519)
IC50
169±n/a nM
Citation
 Djigoué, GB; Kenmogne, LC; Roy, J; Maltais, R; Poirier, D Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17ß-hydroxysteroid dehydrogenase type 3. Bioorg Med Chem 23:5433-51 (2015) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 3
Synonyms:
DHB3_RAT | Edh17b3 | Hsd17b3 | Testosterone 17-beta-dehydrogenase 3
Type:
PROTEIN
Mol. Mass.:
34235.73
Organism:
Rattus norvegicus
Description:
ChEMBL_1510493
Residue:
306
Sequence:
MEQFLLSVGLLVCLVCLVKCVRFSRYLFLSFCKALPGSFLRSMGQWAVITGAGDGIGKAYSFELARHGLNVVLISRTLEKLQVISEEIERTTGSRVKVVQADFTREDIYDHIEEQLKGLEIGVLVNNVGMLPNLLPSHFLSTSGESQSVIHCNITSVVKMTQLVLKHMESRRRGLILNISSGVGVRPWPLYSLYSASKAFVCTFSKALNVEYRDKGIIIQVLTPYSVSTPMTKYLNTSRVTKTADEFVKESLKYVTIGAETCGCLAHEILAIILNLIPSRIFYSSTTQRFLLKQFSDYLKSNISNR
  
Inhibitor
Name:
BDBM91713
Synonyms:
Androst-4-en-3,17-dione, 2 | Androst-4-ene-3,17-dione (3) | Androstenedione
Type:
Small organic molecule
Emp. Form.:
C19H26O2
Mol. Mass.:
286.4085
SMILES:
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CCC2=O |t:8|
Structure:
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