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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50112371
Substrate
n/a
Meas. Tech.
ChEMBL_1513553 (CHEMBL3610010)
IC50
5.0±n/a nM
Citation
 Wang, Y; Cai, W; Cheng, Y; Yang, T; Liu, Q; Zhang, G; Meng, Q; Han, F; Huang, Y; Zhou, L; Xiang, Z; Zhao, YG; Xu, Y; Cheng, Z; Lu, S; Wu, Q; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant ROR¿t Inhibitors. ACS Med Chem Lett 6:787-92 (2015) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50112371
Synonyms:
CHEMBL3609403
Type:
Small organic molecule
Emp. Form.:
C26H21F3N2O5S
Mol. Mass.:
530.516
SMILES:
CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(c2)-c2ccno2)-c2ccccc2OC(F)(F)F)cc1
Structure:
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