Reaction Details Report a problem with these data
Target
Glyceraldehyde-3-phosphate dehydrogenase
Ligand
BDBM50114358
Substrate
n/a
Meas. Tech.
ChEMBL_1511315 (CHEMBL3606220)
IC50
1410±n/a nM
Citation
 Prati, F; Bergamini, C; Molina, MT; Falchi, F; Cavalli, A; Kaiser, M; Brun, R; Fato, R; Bolognesi, ML 2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile. J Med Chem 58:6422-34 (2015) [PubMed]  Article 
Target
Name:
Glyceraldehyde-3-phosphate dehydrogenase
Synonyms:
G3P_HUMAN | GAPD | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase liver | glyceraldehyde-3-phosphate dehydrogenase
Type:
PROTEIN
Mol. Mass.:
36060.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1511315
Residue:
335
Sequence:
MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE
  
Inhibitor
Name:
BDBM50114358
Synonyms:
CHEMBL3604098
Type:
Small organic molecule
Emp. Form.:
C21H14O4
Mol. Mass.:
330.3335
SMILES:
COc1ccc(OC2=CC(=O)c3cc4ccccc4cc3C2=O)cc1 |t:7|
Structure:
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