Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50442941
Substrate
n/a
Meas. Tech.
ChEMBL_1514638 (CHEMBL3614385)
IC50
398±n/a nM
Citation
 Patel, JZ; van Bruchem, J; Laitinen, T; Kaczor, AA; Navia-Paldanius, D; Parkkari, T; Savinainen, JR; Laitinen, JT; Nevalainen, TJ Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors. Bioorg Med Chem 23:6335-45 (2015) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50442941
Synonyms:
CHEMBL3087178
Type:
Small organic molecule
Emp. Form.:
C16H14N2O4
Mol. Mass.:
298.2934
SMILES:
COc1nn(Cc2ccc(Oc3ccccc3)cc2)c(=O)o1
Structure:
Search PDB for entries with ligand similarity: