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Target
Transient receptor potential cation channel subfamily V member 4
Ligand
BDBM50117636
Substrate
n/a
Meas. Tech.
ChEMBL_1514431 (CHEMBL3615627)
IC50
57±n/a nM
Citation
Wei, ZL; Nguyen, MT; O'Mahony, DJ; Acevedo, A; Zipfel, S; Zhang, Q; Liu, L; Dourado, M; Chi, C; Yip, V; DeFalco, J; Gustafson, A; Emerling, DE; Kelly, MG; Kincaid, J; Vincent, F; Duncton, MA Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg Med Chem Lett 25:4011-5 (2015) [PubMed] Article
More Info.:
Target
Name:
Transient receptor potential cation channel subfamily V member 4
Synonyms:
TRPV4_MOUSE | Trp12 | Trpv4 | Vrl2 | Vroac
Type:
PROTEIN
Mol. Mass.:
98032.61
Organism:
Mus musculus
Description:
ChEMBL_1514430
Residue:
871
Sequence:
MADPGDGPRAAPGEVAEPPGDESGTSGGEAFPLSSLANLFEGEEGSSSLSPVDASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVVEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLSFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTSLHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTSIKDLFTKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCDEDQSNCTVPTYPACRDSETFSAFLLDLFKLTIGMGDLEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKSEIYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSSADEVVVPLDNLGNPNCDGHQQGYAPKWRTDDAPL