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Target
Phosphatidylcholine:ceramide cholinephosphotransferase 1
Ligand
BDBM50117833
Substrate
n/a
Meas. Tech.
ChEMBL_1515874 (CHEMBL3614737)
IC50
>100000±n/a nM
Citation
 Li, YL; Qi, XY; Jiang, H; Deng, XD; Dong, YP; Ding, TB; Zhou, L; Men, P; Chu, Y; Wang, RX; Jiang, XC; Ye, DY Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors. Bioorg Med Chem 23:6173-84 (2015) [PubMed]  Article 
Target
Name:
Phosphatidylcholine:ceramide cholinephosphotransferase 1
Synonyms:
MOB | Medulla oblongata-derived protein | Protein Mob | SGMS1 | SMS1 | SMS1_HUMAN | Sphingomyelin synthase 1 | TMEM23 | Transmembrane protein 23
Type:
PROTEIN
Mol. Mass.:
48630.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109868
Residue:
413
Sequence:
MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRLLDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPMPELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
  
Inhibitor
Name:
BDBM50117833
Synonyms:
CHEMBL3613976
Type:
Small organic molecule
Emp. Form.:
C24H23ClN2O3
Mol. Mass.:
422.904
SMILES:
Clc1ccc(CNC(=O)COc2ccc(cc2)C(=O)NCCc2ccccc2)cc1
Structure:
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