Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] A
Ligand
BDBM77817
Substrate
n/a
Meas. Tech.
ChEMBL_1514157 (CHEMBL3614600)
IC50
>100000±n/a nM
Citation
 Choi, JW; Jang, BK; Cho, NC; Park, JH; Yeon, SK; Ju, EJ; Lee, YS; Han, G; Pae, AN; Kim, DJ; Park, KD Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors. Bioorg Med Chem 23:6486-96 (2015) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM77817
Synonyms:
(E)-3-(2-chlorophenyl)-N-phenyl-2-propenamide | (E)-3-(2-chlorophenyl)-N-phenyl-acrylamide | (E)-3-(2-chlorophenyl)-N-phenyl-prop-2-enamide | (E)-3-(2-chlorophenyl)-N-phenylprop-2-enamide | MLS000859034 | N1-phenyl-3-(2-chlorophenyl)acrylamide | SMR000459213 | cid_737170
Type:
Small organic molecule
Emp. Form.:
C15H12ClNO
Mol. Mass.:
257.715
SMILES:
Clc1ccccc1\C=C\C(=O)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity: