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Target
CCR4-NOT transcription complex subunit 7
Ligand
BDBM50119806
Substrate
n/a
Meas. Tech.
ChEMBL_1518114 (CHEMBL3619397)
IC50
4800±n/a nM
Citation
Jadhav, GP; Kaur, I; Maryati, M; Airhihen, B; Fischer, PM; Winkler, GS Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1. Bioorg Med Chem Lett 25:4219-24 (2015) [PubMed] Article
More Info.:
Target
Name:
CCR4-NOT transcription complex subunit 7
Synonyms:
BTG1-binding factor 1 | CAF-1 | CAF1 | CCR4-NOT transcription complex subunit 7 | CCR4-associated factor 1 | CNOT7 | CNOT7_HUMAN | Caf1a
Type:
PROTEIN
Mol. Mass.:
32730.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109881
Residue:
285
Sequence:
MPAATVDHSQRICEVWACNLDEEMKKIRQVIRKYNYVAMDTEFPGVVARPIGEFRSNADYQYQLLRCNVDLLKIIQLGLTFMNEQGEYPPGTSTWQFNFKFNLTEDMYAQDSIELLTTSGIQFKKHEEEGIETQYFAELLMTSGVVLCEGVKWLSFHSGYDFGYLIKILTNSNLPEEELDFFEILRLFFPVIYDVKYLMKSCKNLKGGLQEVAEQLELERIGPQHQAGSDSLLTGMAFFKMREMFFEDHIDDAKYCGHLYGLGSGSSYVQNGTGNAYEEEANKQS