Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50120670
Substrate
n/a
Meas. Tech.
ChEMBL_1518193 (CHEMBL3619840)
Ki
2.3±n/a nM
Citation
 Devasthale, PWang, WMignone, JRenduchintala, KRadhakrishnan, SDhanapal, JSelvaraj, JKuppusamy, RPelleymounter, MALonghi, DHuang, NFlynn, NAzzara, AVRohrbach, KDevenny, JRooney, SThomas, MGlick, SGodonis, HHarvey, SCullen, MJZhang, HCaporuscio, CStetsko, PGrubb, MHuang, CZhang, LFreeden, CMurphy, BJRobl, JAWashburn, WN Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies. Bioorg Med Chem Lett 25:4412-8 (2015) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39075.64
Organism:
RAT
Description:
Melanin Concentrating Hormone 1 GPR24 RAT::P97639
Residue:
353
Sequence:
MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50120670
Synonyms:
CHEMBL3618338
Type:
Small organic molecule
Emp. Form.:
C23H21ClN4O4
Mol. Mass.:
452.89
SMILES:
COc1cc(ccc1N1C[C@H](O)[C@H](O)C1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cc1 |r|
Structure:
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