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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50120904
Substrate
n/a
Meas. Tech.
ChEMBL_1520751 (CHEMBL3625774)
IC50
34±n/a nM
Citation
 Lloyd, J; Finlay, HJ; Kover, A; Johnson, J; Pi, Z; Jiang, J; Neels, J; Cavallaro, C; Wexler, R; Conder, ML; Shi, H; Li, D; Sun, H; Chimalakonda, A; Huang, C; Salvati, M; Levesque, P Pseudosaccharin amines as potent and selective KV1.5 blockers. Bioorg Med Chem Lett 25:4983-6 (2015) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50120904
Synonyms:
CHEMBL3622346
Type:
Small organic molecule
Emp. Form.:
C21H24N2O4S
Mol. Mass.:
400.491
SMILES:
COc1cccc2c1C(NC[C@@]1(CC[C@H](O)CC1)c1ccccc1)=NS2(=O)=O |r,wU:14.15,11.11,c:26,(-2.09,3.71,;-1.02,3.09,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;.3,.77,;1.76,1.24,;2.24,2.7,;3.75,3.01,;4.23,4.48,;4.74,5.91,;3.71,7.06,;2.2,6.74,;1.38,7.66,;1.72,5.28,;2.75,4.13,;5.74,4.79,;6.76,3.65,;8.27,3.96,;8.75,5.43,;7.72,6.57,;6.22,6.26,;2.66,.02,;1.76,-1.24,;.93,-2.14,;2.97,-1.47,)|
Structure:
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