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Target
Solute carrier family 40 member 1
Ligand
BDBM50120956
Substrate
n/a
Meas. Tech.
ChEMBL_1520975 (CHEMBL3624279)
EC50
335±n/a nM
Citation
 Chua, K; Fung, E; Micewicz, ED; Ganz, T; Nemeth, E; Ruchala, P Small cyclic agonists of iron regulatory hormone hepcidin. Bioorg Med Chem Lett 25:4961-9 (2015) [PubMed]  Article 
Target
Name:
Solute carrier family 40 member 1
Synonyms:
FPN | FPN1 | FPN1 | Ferroportin-1 | IREG1 | Iron-regulated transporter 1 | S40A1_HUMAN | SLC11A3 | SLC40A1 | Solute carrier family 40 member 1
Type:
PROTEIN
Mol. Mass.:
62541.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109560
Residue:
571
Sequence:
MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV
  
Inhibitor
Name:
BDBM50120956
Synonyms:
CHEMBL3621372
Type:
Small organic molecule
Emp. Form.:
C53H69N13O7S3
Mol. Mass.:
1096.393
SMILES:
NC(=N)NCCC[C@@H]1NC(=O)[C@@H](CSCc2cccc(CSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC1=O)C(N)=O)c2)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Structure:
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