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Target
Solute carrier family 40 member 1
Ligand
BDBM50120990
Substrate
n/a
Meas. Tech.
ChEMBL_1520975 (CHEMBL3624279)
EC50
4.2±n/a nM
Citation
 Chua, K; Fung, E; Micewicz, ED; Ganz, T; Nemeth, E; Ruchala, P Small cyclic agonists of iron regulatory hormone hepcidin. Bioorg Med Chem Lett 25:4961-9 (2015) [PubMed]  Article 
Target
Name:
Solute carrier family 40 member 1
Synonyms:
FPN | FPN1 | FPN1 | Ferroportin-1 | IREG1 | Iron-regulated transporter 1 | S40A1_HUMAN | SLC11A3 | SLC40A1 | Solute carrier family 40 member 1
Type:
PROTEIN
Mol. Mass.:
62541.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109560
Residue:
571
Sequence:
MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV
  
Inhibitor
Name:
BDBM50120990
Synonyms:
CHEMBL3623057
Type:
Small organic molecule
Emp. Form.:
C86H133N21O15S
Mol. Mass.:
1733.173
SMILES:
CCCCCCCCCCCCCCCCNC(=O)CN(CC(N)=O)C(=O)CCCCCNC(=O)C[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC(=O)C[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)CNCC(O)=O)[C@@H](C)O)C(c1ccccc1)c1ccccc1 |r|
Structure:
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