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Target
Nucleoprotein
Ligand
BDBM50121392
Substrate
n/a
Meas. Tech.
ChEMBL_1518462 (CHEMBL3621015)
IC50
1700±n/a nM
Citation
 Lin, MI; Su, BH; Lee, CH; Wang, ST; Wu, WC; Dangate, P; Wang, SY; Huang, WI; Cheng, TJ; Lin, OA; Cheng, YS; Tseng, YJ; Sun, CM Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1. Eur J Med Chem 102:477-86 (2015) [PubMed]  Article 
Target
Name:
Nucleoprotein
Synonyms:
NCAP_I33A0 | NP | Nucleocapsid protein | Nucleoprotein | Protein N
Type:
PROTEIN
Mol. Mass.:
56258.29
Organism:
Influenza A virus (strain A/Wilson-Smith/1933 H1N1)
Description:
ChEMBL_109971
Residue:
498
Sequence:
MATKGTKRSYEQMETDGERQNATEIRASVGKMIGGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRVDGKWMRELILYDKEEIRRIWRQANNGDDATAGLTHMMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMVDQVRESRNPGNAEFEDLIFLARSALILRGSVAHKSCLPACVYGPAVASGYDFEREGYSLVGIDPFRLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTKVVPRGKLSTRGVQIASNENMETMESSTLELRSRYWAIRTRSGGNTNQQRASSGQISIQPTFSVQRNLPFDRPTIMAAFTGNTEGRTSDMRTEIIRLMESARPEDVSFQGRGVFELSDEKAASPIVPSFDMSNEGSYFFGDNAEEYDN
  
Inhibitor
Name:
BDBM50121392
Synonyms:
CHEMBL3616822
Type:
Small organic molecule
Emp. Form.:
C25H24FN3O3
Mol. Mass.:
433.4748
SMILES:
Cn1c2c3C(OCC(C)(C)n3c(-c3ccccc3)c2c(=O)n(C)c1=O)c1ccccc1F
Structure:
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