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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM203466
Substrate
n/a
Meas. Tech.
ChEMBL_1520136 (CHEMBL3625600)
IC50
25±n/a nM
Citation
 Seganish, WM; Fischmann, TO; Sherborne, B; Matasi, J; Lavey, B; McElroy, WT; Tulshian, D; Tata, J; Sondey, C; Garlisi, CG; Devito, K; Fossetta, J; Lundell, D; Niu, X Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors. ACS Med Chem Lett 6:942-7 (2015) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM203466
Synonyms:
US9221809, 3
Type:
Small organic molecule
Emp. Form.:
C20H23N5O4S
Mol. Mass.:
429.493
SMILES:
OC[C@H]1C[C@@H](Nc2nc(NC3CC3)[nH]c(=O)c2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O |r|
Structure:
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