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Target
NAD-dependent protein deacylase sirtuin-6
Ligand
BDBM50123364
Substrate
n/a
Meas. Tech.
ChEMBL_1520799 (CHEMBL3625953)
IC50
37000±n/a nM
Citation
 Sociali, G; Galeno, L; Parenti, MD; Grozio, A; Bauer, I; Passalacqua, M; Boero, S; Donadini, A; Millo, E; Bellotti, M; Sturla, L; Damonte, P; Puddu, A; Ferroni, C; Varchi, G; Franceschi, C; Ballestrero, A; Poggi, A; Bruzzone, S; Nencioni, A; Del Rio, A Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics. Eur J Med Chem 102:530-9 (2015) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacylase sirtuin-6
Synonyms:
NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6)
Type:
Protein
Mol. Mass.:
39133.03
Organism:
Homo sapiens (Human)
Description:
Q8N6T7
Residue:
355
Sequence:
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
  
Inhibitor
Name:
BDBM50123364
Synonyms:
CHEMBL3622696
Type:
Small organic molecule
Emp. Form.:
C21H18N4O4S
Mol. Mass.:
422.457
SMILES:
O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1cccc(CCc2ccncc2)c1
Structure:
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