Reaction Details Report a problem with these data
Target
Protein-serine O-palmitoleoyltransferase porcupine
Ligand
BDBM50125898
Substrate
n/a
Meas. Tech.
ChEMBL_1519628 (CHEMBL3626166)
IC50
>1000±n/a nM
Citation
 Dong, Y; Li, K; Xu, Z; Ma, H; Zheng, J; Hu, Z; He, S; Wu, Y; Sun, Z; Luo, L; Li, J; Zhang, H; Zhang, X Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors. Bioorg Med Chem 23:6855-68 (2015) [PubMed]  Article 
Target
Name:
Protein-serine O-palmitoleoyltransferase porcupine
Synonyms:
MG61 | MG61 | PORC | PORCN | PORCN_HUMAN | PPN | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein MG61 | Protein-serine O-palmitoleoyltransferase porcupine
Type:
PROTEIN
Mol. Mass.:
52337.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103574
Residue:
461
Sequence:
MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
  
Inhibitor
Name:
BDBM50125898
Synonyms:
CHEMBL3623880
Type:
Small organic molecule
Emp. Form.:
C21H16N4O2
Mol. Mass.:
356.3773
SMILES:
O=C(COc1ccc2ccccc2c1)Nc1ccc(cn1)-c1cnccn1
Structure:
Search PDB for entries with ligand similarity: