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Target
Kynurenine 3-monooxygenase
Ligand
BDBM50126147
Substrate
n/a
Meas. Tech.
ChEMBL_1523467 (CHEMBL3630811)
IC50
74±n/a nM
Citation
 Dounay, AB; Tuttle, JB; Verhoest, PR Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway. J Med Chem 58:8762-82 (2015) [PubMed]  Article 
Target
Name:
Kynurenine 3-monooxygenase
Synonyms:
BNA4 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD10 or PARP10) | KMO_YEAST
Type:
n/a
Mol. Mass.:
52440.50
Organism:
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Description:
n/a
Residue:
460
Sequence:
MSESVAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTTKNKNLKSINLAISARGIDALKSIDPDACEHILQDMIPMKGRMIHDLKGRQESQLYGLHGEAINSINRSVLNNSLLDELEKSTTELKFGHKLVKIEWTDDKQICHFAIGEDLKTPHTEKYDFVIGCDGAYSATRSQMQRKVEMDFSQEYMNLRYIELYIPPTEEFKPNYGGNFAIAPDHLHIWPRHKFMLIALANSDGSFTSTFFGSKDQISDLITSKSRVREFLIENFPDIINIMDLDDAVKRFITYPKESLVCVNCKPYDVPGGKAILLGDAAHAMVPFYGQGMNCGFEDVRILMALLKKHSGDRSRAFTEYTQTRHKDLVSITELAKRNYKEMSHDVTSKRFLLRKKLDALFSIIMKDKWIPLYTMISFRSDISYSRALERAGKQTRILKFLESLTLGMLSIGGYKLFKFLTRERS
  
Inhibitor
Name:
BDBM50126147
Synonyms:
CHEMBL3629571
Type:
Small organic molecule
Emp. Form.:
C11H8Cl2O3
Mol. Mass.:
259.085
SMILES:
OC(=O)C1CC1C(=O)c1ccc(Cl)c(Cl)c1
Structure:
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