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TargetCoagulation factor IX
LigandBDBM50126919
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1524004
Ki 0.600000±n/a nM
Citation Meng, DAndre, PBateman, TJBerger, RChen, YHDesai, KDewnani, SEllsworth, KFeng, DGeissler, WMGuo, LHruza, AJian, TLi, HMetzger, JParker, DLReichert, PSherer, ECSmith, CJSonatore, LMTschirret-Guth, RWu, JXu, JZhang, TCampeau, LCOrr, RPoirier, MMcCabe-Dunn, JAraki, KNishimura, TSakurada, IHirabayashi, TWood, HB Development of a novel tricyclic class of potent and selective FIXa inhibitors. Bioorg Med Chem Lett25:5437-43 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor IX
Name:Coagulation factor IX
Synonyms:Christmas factor | Coagulation factor IX precursor | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:Enzyme
Mol. Mass.:51768.83
Organism:Homo sapiens (Human)
Description:n/a
Residue:461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50126919
NameBDBM50126919
Synonyms:CHEMBL3629114
TypeSmall organic molecule
Emp. Form.C30H25Cl2N5O3
Mol. Mass.574.457
SMILESCc1ncn(n1)-c1cc(Cl)c(C(=O)N[C@@]2(CCc3c(C(O)=O)c4cc(C)ccc4n3C2)c2ccccc2)c(Cl)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a