Target
Coagulation factor X
Ligand
BDBM50126954
Substrate
n/a
Meas. Tech.
ChEMBL_1524005 (CHEMBL3630477)
Ki
3283±n/a nM
Citation
 Meng, DAndre, PBateman, TJBerger, RChen, YHDesai, KDewnani, SEllsworth, KFeng, DGeissler, WMGuo, LHruza, AJian, TLi, HMetzger, JParker, DLReichert, PSherer, ECSmith, CJSonatore, LMTschirret-Guth, RWu, JXu, JZhang, TCampeau, LCOrr, RPoirier, MMcCabe-Dunn, JAraki, KNishimura, TSakurada, IHirabayashi, TWood, HB Development of a novel tricyclic class of potent and selective FIXa inhibitors. Bioorg Med Chem Lett 25:5437-43 (2015) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50126954
Synonyms:
CHEMBL3628959
Type:
Small organic molecule
Emp. Form.:
C29H22Cl2F3N5O
Mol. Mass.:
584.419
SMILES:
Cc1ccc2n3C[C@@](CCc3c(c2c1)C(F)(F)F)(NC(=O)c1c(Cl)cc(cc1Cl)-n1cnnc1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: