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Target
Beta-galactoside alpha-2,6-sialyltransferase 1
Ligand
BDBM50127703
Substrate
n/a
Meas. Tech.
ChEMBL_1522838 (CHEMBL3630397)
Ki
28±n/a nM
Citation
 Li, W; Niu, Y; Xiong, DC; Cao, X; Ye, XS Highly Substituted Cyclopentane-CMP Conjugates as Potent Sialyltransferase Inhibitors. J Med Chem 58:7972-90 (2015) [PubMed]  Article 
Target
Name:
Beta-galactoside alpha-2,6-sialyltransferase 1
Synonyms:
Alpha 2,6-ST 1 | B-cell antigen CD75 | Beta-galactoside alpha-2,6-sialyltransferase 1 | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1 | SIAT1 | SIAT1_HUMAN | ST6GAL1 | ST6Gal I | ST6GalI | Sialyltransferase 1
Type:
PROTEIN
Mol. Mass.:
46622.19
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109837
Residue:
406
Sequence:
MIHTNLKKKFSCCVLVFLLFAVICVWKEKKKGSYYDSFKLQTKEFQVLKSLGKLAMGSDSQSVSSSSTQDPHRGRQTLGSLRGLAKAKPEASFQVWNKDSSSKNLIPRLQKIWKNYLSMNKYKVSYKGPGPGIKFSAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHLNQGTDEDIYLLGKATLPGFRTIHC
  
Inhibitor
Name:
BDBM50127703
Synonyms:
CHEMBL3629696
Type:
Small organic molecule
Emp. Form.:
C24H31N4Na3O13P2
Mol. Mass.:
714.4388
SMILES:
[Na+].[Na+].[Na+].CC(=O)NC[C@@H]1CCC(OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(N)nc2=O)([C@H]1OCc1ccccc1)P([O-])([O-])=O |r|
Structure:
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