Reaction Details Report a problem with these data
Target
Tumor necrosis factor ligand superfamily member 11
Ligand
BDBM50128344
Substrate
n/a
Meas. Tech.
ChEMBL_1523723 (CHEMBL3631862)
IC50
580±n/a nM
Citation
 Kang, JH; Ting, Z; Moon, MR; Sim, JS; Lee, JM; Doh, KE; Hong, S; Cui, M; Choi, S; Chang, HW; Park Choo, HY; Yim, M 5-Lipoxygenase inhibitors suppress RANKL-induced osteoclast formation via NFATc1 expression. Bioorg Med Chem 23:7069-78 (2015) [PubMed]  Article 
Target
Name:
Tumor necrosis factor ligand superfamily member 11
Synonyms:
CD_antigen=CD254 | ODF | Opgl | Osteoclast differentiation factor | Osteoprotegerin ligand | Rankl | Receptor activator of nuclear factor kappa-B ligand | TNF-related activation-induced cytokine | TNF11_MOUSE | Tnfsf11 | Trance | Tumor necrosis factor ligand superfamily member 11, membrane form | Tumor necrosis factor ligand superfamily member 11, soluble form
Type:
PROTEIN
Mol. Mass.:
35008.20
Organism:
Mus musculus
Description:
ChEMBL_109846
Residue:
316
Sequence:
MRRASRDYGKYLRSSEEMGSGPGVPHEGPLHPAPSAPAPAPPPAASRSMFLALLGLGLGQVVCSIALFLYFRAQMDPNRISEDSTHCFYRILRLHENADLQDSTLESEDTLPDSCRRMKQAFQGAVQKELQHIVGPQRFSGAPAMMEGSWLDVAQRGKPEAQPFAHLTINAASIPSGSHKVTLSSWYHDRGWAKISNMTLSNGKLRVNQDGFYYLYANICFRHHETSGSVPTDYLQLMVYVVKTSIKIPSSHNLMKGGSTKNWSGNSEFHFYSINVGGFFKLRAGEEISIQVSNPSLLDPDQDATYFGAFKVQDID
  
Inhibitor
Name:
BDBM50128344
Synonyms:
CHEMBL3629177
Type:
Small organic molecule
Emp. Form.:
C26H27N5O5
Mol. Mass.:
489.5231
SMILES:
COc1ccc(Nc2nc3cc(NC(=O)CCCCOc4ccc(cc4)C(\N)=N\O)ccc3o2)cc1
Structure:
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