Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50128362
Substrate
n/a
Meas. Tech.
ChEMBL_1523859 (CHEMBL3632420)
EC50
70±n/a nM
Citation
 Dai, X; Stamford, A; Liu, H; Neustadt, B; Hao, J; Kowalski, T; Hawes, B; Xu, X; Baker, H; O'Neill, K; Woods, M; Tang, H; Greenlee, W Discovery of the oxazabicyclo[3.3.1]nonane derivatives as potent and orally active GPR119 agonists. Bioorg Med Chem Lett 25:5291-4 (2015) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50128362
Synonyms:
CHEMBL3629483
Type:
Small organic molecule
Emp. Form.:
C24H29FN4O6S
Mol. Mass.:
520.574
SMILES:
Cc1c(Nc2ccc(cc2F)S(C)(=O)=O)ncnc1OC1CC2COCC(C1)N2C(=O)OC1(C)CC1 |THB:19:20:23.24.25:28|
Structure:
Search PDB for entries with ligand similarity: