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Target
Procathepsin L
Ligand
BDBM50128811
Substrate
n/a
Meas. Tech.
ChEMBL_1522723 (CHEMBL3629949)
IC50
24±n/a nM
Citation
 Parker, EN; Song, J; Kishore Kumar, GD; Odutola, SO; Chavarria, GE; Charlton-Sevcik, AK; Strecker, TE; Barnes, AL; Sudhan, DR; Wittenborn, TR; Siemann, DW; Horsman, MR; Chaplin, DJ; Trawick, ML; Pinney, KG Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L. Bioorg Med Chem 23:6974-92 (2015) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50128811
Synonyms:
CHEMBL3629193
Type:
Small organic molecule
Emp. Form.:
C21H19N3OS
Mol. Mass.:
361.46
SMILES:
NC(=S)N\N=C(/c1ccccc1)c1cccc(c1)C(O)c1ccccc1
Structure:
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