Reaction Details Report a problem with these data
Target
P2Y purinoceptor 1
Ligand
BDBM50131059
Substrate
n/a
Meas. Tech.
ChEMBL_1526464 (CHEMBL3637733)
EC50
130±n/a nM
Citation
 Azran, S; Danino, O; Förster, D; Kenigsberg, S; Reiser, G; Dixit, M; Singh, V; Major, DT; Fischer, B Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action. J Med Chem 58:8427-43 (2015) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 1
Synonyms:
ATP receptor | P2RY1 | P2RY1_HUMAN | P2Y purinoceptor 1 (P2Y1) | P2Y1 | Purinergic receptor | Purinergic receptor P2Y1
Type:
Enzyme
Mol. Mass.:
42090.25
Organism:
Homo sapiens (Human)
Description:
P47900
Residue:
373
Sequence:
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL
  
Inhibitor
Name:
BDBM50131059
Synonyms:
CHEMBL575257
Type:
Small organic molecule
Emp. Form.:
C10H15N5O9P2S
Mol. Mass.:
443.267
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(S)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Structure:
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