Reaction Details Report a problem with these data
Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Ligand
BDBM50133328
Substrate
n/a
Meas. Tech.
ChEMBL_1525781 (CHEMBL3635350)
IC50
400±n/a nM
Citation
 Lim, SM; Jeong, Y; Lee, S; Im, H; Tae, HS; Kim, BG; Park, HD; Park, J; Hong, S Identification of฿-Lapachone Analogs as Novel MALT1 Inhibitors To Treat an Aggressive Subtype of Diffuse Large B-Cell Lymphoma. J Med Chem 58:8491-502 (2015) [PubMed]  Article 
Target
Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms:
MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase
Type:
Enzyme
Mol. Mass.:
92257.81
Organism:
Homo sapiens (Human)
Description:
Q9UDY8
Residue:
824
Sequence:
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
  
Inhibitor
Name:
BDBM50133328
Synonyms:
CHEMBL3632807
Type:
Small organic molecule
Emp. Form.:
C15H13NO5
Mol. Mass.:
287.2674
SMILES:
CC1(C)CCC2=C(O1)c1ccc(cc1C(=O)C2=O)[N+]([O-])=O |c:5|
Structure:
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