Reaction Details
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Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Ligand
BDBM50133487
Substrate
n/a
Meas. Tech.
ChEMBL_1525967 (CHEMBL3635791)
IC50
4200±n/a nM
Citation
Nakagawa, H; Seike, S; Sugimoto, M; Ieda, N; Kawaguchi, M; Suzuki, T; Miyata, N Peptidyl prolyl isomerase Pin1-inhibitory activity of D-glutamic and D-aspartic acid derivatives bearing a cyclic aliphatic amine moiety. Bioorg Med Chem Lett 25:5619-24 (2015) [PubMed] Article More Info.:
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms:
PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Type:
PROTEIN
Mol. Mass.:
18248.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502595
Residue:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
Inhibitor
Name:
BDBM50133487
Synonyms:
CHEMBL3633019
Type:
Small organic molecule
Emp. Form.:
C24H21N3O3
Mol. Mass.:
399.4418
SMILES:
Cn1nc(cc1C(=O)NC(Cc1ccc2ccccc2c1)C(O)=O)-c1ccccc1
Structure:
