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Target
G-protein coupled receptor family C group 6 member A
Ligand
BDBM50133683
Substrate
n/a
Meas. Tech.
ChEMBL_1526359 (CHEMBL3637420)
IC50
245471±n/a nM
Citation
 Johansson, H; Boesgaard, MW; Nørskov-Lauritsen, L; Larsen, I; Kuhne, S; Gloriam, DE; Bräuner-Osborne, H; Sejer Pedersen, D Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold. J Med Chem 58:8938-51 (2015) [PubMed]  Article 
Target
Name:
G-protein coupled receptor family C group 6 member A
Synonyms:
G-protein coupled receptor family C group 6 member A | GPC6A_MOUSE | Gprc6a
Type:
PROTEIN
Mol. Mass.:
104230.70
Organism:
Mus musculus
Description:
ChEMBL_109502
Residue:
928
Sequence:
MALLITVVTCFMIILDTSQSCHTPDDFVAITSPGHIMIGGLFAIHEKMLSSDDHPRRPQIQKCAGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDTCTEVTAAMAATLRFLSKFNCSRETVVFQCDYSSYMPRVKAVIGAGYSETSIAVSRMLNLQLMPQVSYESTAEILSDKIRFPSFLRTVPSDFYQTKAMAHLIRQSGWNWIGAITTDDDYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEVRINQTLEKIIAEAQVNVIVVFLRKFHVFNLFTKAIERKISKIWIASDNWSTATKIITIPNVKKLGKVVGFAFRRGNTSSFHSFLQTLHMYPNDNNKPLHEFAMLVSACKYIKDGDLSQCISNYSQATLTYDTTKTIENHLFKRNDFLWHYTEPGLIYSIQLAVFALGHAIRDLCQARDCKKPNAFQPWELLAVLKNVTFTDGRNSFHFDAHGDLNTGYDVVLWKETNGLMTVTKMAEYDLQRDVFITTNQETKHEFRKLKQILSKCSKECSPGQMKKATGSQHSCCYECVSCPENHYSNETDMDHCLLCNNETHWAPVRSTTCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAIGIIFTRNLKTPVVKSSGGLVVCYVMLICHALNFASTGFFIGEPQDFACKTRQTLFGVSFTLCVSCILTKSLKILLAFSFDPKLTMFLKCLYRPVPIVLTCTGIQVVICTLWLVLAAPSVEENISLPRVIILECEEGSALAFGTMLGYITVLAFICFVFAFKGRKLPENYNEAKFLTFGMLIYFIAWITFIPVYTTTFGKYLPAVEIIVILISNYGILCCIFFPKCYIILCKQKTNTKSAFLQMVYNYSAHSVDSLALSHVSLDSTSYDTATTNQSPGNKMTACQNDNHLPAQVLPHTGTAKTIKASKTLRQKRSSSI
  
Inhibitor
Name:
BDBM50133683
Synonyms:
CHEMBL3633657
Type:
Small organic molecule
Emp. Form.:
C21H23N3O4
Mol. Mass.:
381.425
SMILES:
CN(CC(=O)N1CCOCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: