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TargetProtein-serine O-palmitoleoyltransferase porcupine
LigandBDBM50133867
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1526513
IC50 5400±n/a nM
Citation Ho, SYKeller, TH The use of porcupine inhibitors to target Wnt-driven cancers. Bioorg Med Chem Lett25:5472-6 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Protein-serine O-palmitoleoyltransferase porcupine
Name:Protein-serine O-palmitoleoyltransferase porcupine
Synonyms:2.3.1.- | MG61 | PORC | PORCN | PPN | Protein MG61 | Protein-serine O-palmitoleoyltransferase porcupine
Type:PROTEIN
Mol. Mass.:52337.13
Organism:Homo sapiens
Description:ChEMBL_103574
Residue:461
Sequence:
MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGG
FFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTW
HKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV
QGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVR
WLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVE
VVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYV
EHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVD
VDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50133867
NameBDBM50133867
Synonyms:CHEMBL3633803
TypeSmall organic molecule
Emp. Form.C20H19N5O3S
Mol. Mass.409.462
SMILESC[C@H](C(=O)Nc1ccc(cc1)-c1ccsc1)n1cnc2n(C)c(=O)n(C)c(=O)c12 |r|
Structure
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n/a