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Target
Protein-serine O-palmitoleoyltransferase porcupine
Ligand
BDBM50428029
Substrate
n/a
Meas. Tech.
ChEMBL_1526512 (CHEMBL3635400)
IC50
60±n/a nM
Citation
 Ho, SY; Keller, TH The use of porcupine inhibitors to target Wnt-driven cancers. Bioorg Med Chem Lett 25:5472-6 (2015) [PubMed]  Article 
Target
Name:
Protein-serine O-palmitoleoyltransferase porcupine
Synonyms:
MG61 | MG61 | PORC | PORCN | PORCN_HUMAN | PPN | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein MG61 | Protein-serine O-palmitoleoyltransferase porcupine
Type:
PROTEIN
Mol. Mass.:
52337.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103574
Residue:
461
Sequence:
MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
  
Inhibitor
Name:
BDBM50428029
Synonyms:
CHEMBL1257063
Type:
Small organic molecule
Emp. Form.:
C26H21N5O5S
Mol. Mass.:
515.54
SMILES:
COc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(OC)cc3s2)c2ccccc2c1=O
Structure:
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