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TargetProtein-serine O-palmitoleoyltransferase porcupine
LigandBDBM50428029
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1526512
IC50 60±n/a nM
Citation Ho, SYKeller, TH The use of porcupine inhibitors to target Wnt-driven cancers. Bioorg Med Chem Lett25:5472-6 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Protein-serine O-palmitoleoyltransferase porcupine
Name:Protein-serine O-palmitoleoyltransferase porcupine
Synonyms:2.3.1.- | MG61 | PORC | PORCN | PPN | Protein MG61 | Protein-serine O-palmitoleoyltransferase porcupine
Type:PROTEIN
Mol. Mass.:52337.13
Organism:Homo sapiens
Description:ChEMBL_103574
Residue:461
Sequence:
MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGG
FFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTW
HKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV
QGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVR
WLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVE
VVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYV
EHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVD
VDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50428029
NameBDBM50428029
Synonyms:CHEMBL1257063
TypeSmall organic molecule
Emp. Form.C26H21N5O5S
Mol. Mass.515.54
SMILESCOc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(OC)cc3s2)c2ccccc2c1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a