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Target
Mitogen-activated protein kinase 7
Ligand
BDBM50134187
Substrate
n/a
Meas. Tech.
ChEBML_1539778
IC50
220±n/a nM
Citation
Furlotti, G; Alisi, MA; Cazzolla, N; Dragone, P; Durando, L; Magarņ, G; Mancini, F; Mangano, G; Ombrato, R; Vitiello, M; Armirotti, A; Capurro, V; Lanfranco, M; Ottonello, G; Summa, M; Reggiani, A Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders. J Med Chem 58:8920-37 (2015) [PubMed] Article
More Info.:
Target
Name:
Mitogen-activated protein kinase 7
Synonyms:
BMK1 | Big MAP kinase 1 | ERK5 | Extracellular signal-regulated kinase 5 (ERK5) | MAPK7 | MK07_HUMAN | PRKM7
Type:
Protein
Mol. Mass.:
88377.36
Organism:
Homo sapiens (Human)
Description:
Q13164
Residue:
816
Sequence:
MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP