Target
Mitogen-activated protein kinase 7
Ligand
BDBM50134187
Substrate
n/a
Meas. Tech.
ChEBML_1539778
IC50
220±n/a nM
Citation
 Furlotti, GAlisi, MACazzolla, NDragone, PDurando, LMagarņ, GMancini, FMangano, GOmbrato, RVitiello, MArmirotti, ACapurro, VLanfranco, MOttonello, GSumma, MReggiani, A Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders. J Med Chem 58:8920-37 (2015) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 7
Synonyms:
BMK1 | Big MAP kinase 1 | ERK5 | Extracellular signal-regulated kinase 5 (ERK5) | MAPK7 | MK07_HUMAN | PRKM7
Type:
Protein
Mol. Mass.:
88377.36
Organism:
Homo sapiens (Human)
Description:
Q13164
Residue:
816
Sequence:
MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
  
Inhibitor
Name:
BDBM50134187
Synonyms:
CHEMBL3735506 | US11472795, Example C | US9611249, Compound 8
Type:
Small organic molecule
Emp. Form.:
C23H26F2N4O2
Mol. Mass.:
428.4749
SMILES:
COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cccc(F)c2F)CC1
Structure:
Search PDB for entries with ligand similarity: