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Target
Legumain
Ligand
BDBM50134277
Substrate
n/a
Meas. Tech.
ChEMBL_1543634 (CHEMBL3750895)
IC50
1459±n/a nM
Citation
 Ness, KA; Eddie, SL; Burton, S; Harrison, T; Mullan, P; Williams, R Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors. Bioorg Med Chem Lett 26:413-6 (2016) [PubMed]  Article 
Target
Name:
Legumain
Synonyms:
3.4.22.34 | Asparaginyl endopeptidase | LGMN | LGMN_HUMAN | PRSC1 | Protease, cysteine 1
Type:
n/a
Mol. Mass.:
49411.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
433
Sequence:
MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVTHLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASEAEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHRIKLSMDHVCLGHY
  
Inhibitor
Name:
BDBM50134277
Synonyms:
CHEMBL3747178
Type:
Small organic molecule
Emp. Form.:
C21H22F2N4O4S
Mol. Mass.:
464.486
SMILES:
C[C@@H](N(Cc1ccc(cc1)-c1cccc(F)c1F)S(C)(=O)=O)C(=O)N[C@@H](CC(N)=O)C#N |r|
Structure:
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