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Target
Dual specificity mitogen-activated protein kinase kinase 3
Ligand
BDBM50134591
Substrate
n/a
Meas. Tech.
ChEMBL_1544298 (CHEMBL3751415)
IC50
4200±n/a nM
Citation
 Adams, M; Kobayashi, T; Lawson, JD; Saitoh, M; Shimokawa, K; Bigi, SV; Hixon, MS; Smith, CR; Tatamiya, T; Goto, M; Russo, J; Grimshaw, CE; Swann, S Fragment-based drug discovery of potent and selective MKK3/6 inhibitors. Bioorg Med Chem Lett 26:1086-9 (2016) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 3
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 3 | MAP kinase kinase 3 | MAP2K3 | MAPK/ERK kinase 3 | MAPK/ERK kinase 3 (MEK3) | MAPKK 3 | MEK3 | MKK3 | MP2K3_HUMAN | PRKMK3 | SKK2
Type:
Protein
Mol. Mass.:
39321.50
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
347
Sequence:
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
  
Inhibitor
Name:
BDBM50134591
Synonyms:
CHEMBL3745744
Type:
Small organic molecule
Emp. Form.:
C12H11N3O
Mol. Mass.:
213.2352
SMILES:
NC(=O)c1nc(ccc1N)-c1ccccc1
Structure:
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