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TargetDihydrofolate Reductase (DHFR)
LigandBDBM50049905
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1539068
Ki 0.030000±n/a nM
Citation Chao, BLi, BXXiao, X The chemistry and pharmacology of privileged pyrroloquinazolines. Medchemcomm6:510-520 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate Reductase (DHFR)
Name:Dihydrofolate Reductase (DHFR)
Synonyms:Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:22141.77
Organism:Candida albicans
Description:C. albicans DHFR was expressed in E. coli BL21, and purified to homogeneity.
Residue:192
Sequence:
MSKPNVAIIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWE
SIPQKFRPLPDRLNIILSRSYENKIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNE
LINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQPKSELQKFVGDTVLEDDIKEG
DFTYNYTLWTRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50049905
NameBDBM50049905
Synonyms:7-(1-Ethyl-propyl)-8-methyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL170758 | TCMDC-137283
TypeSmall organic molecule
Emp. Form.C16H21N5
Mol. Mass.283.3714
SMILESCCC(CC)n1c(C)cc2c1ccc1nc(N)nc(N)c21
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a