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TargetDihydrofolate reductase
LigandBDBM50049904
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1539066
Ki 1.000000±n/a nM
Citation Chao, BLi, BXXiao, X The chemistry and pharmacology of privileged pyrroloquinazolines. Medchemcomm6:510-520 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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  Blast E-value cutoff:
BDBM50049904
NameBDBM50049904
Synonyms:7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL353764 | TCMDC-124301
TypeSmall organic molecule
Emp. Form.C10H9N5
Mol. Mass.199.212
SMILESNc1nc(N)c2c3cc[nH]c3ccc2n1
Structure
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