Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50135267
Substrate
n/a
Meas. Tech.
ChEMBL_1544357 (CHEMBL3748433)
IC50
1900±n/a nM
Citation
 Abdjul, DB; Kanno, S; Yamazaki, H; Ukai, K; Namikoshi, M A dimeric urea of the bisabolene sesquiterpene from the Okinawan marine sponge Axinyssa sp. inhibits protein tyrosine phosphatase 1B activity in Huh-7 human hepatoma cells. Bioorg Med Chem Lett 26:315-7 (2016) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50135267
Synonyms:
CHEMBL3746974
Type:
Small organic molecule
Emp. Form.:
C31H52N2O
Mol. Mass.:
468.7574
SMILES:
[H][C@]1([#6]-[#6]-[#6](-[#6])=[#6]-[#6]1)[C@]([#6])([#6]-[#6]\[#6]=[#6](\[#6])-[#6])[#7]-[#6](=O)-[#7][C@@]([#6])([#6]-[#6]\[#6]=[#6](\[#6])-[#6])[C@]1([H])[#6]-[#6]-[#6](-[#6])=[#6]-[#6]1 |r,c:5,34|
Structure:
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