Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50138715
Substrate
n/a
Meas. Tech.
ChEMBL_1550085 (CHEMBL3756031)
IC50
1.0±n/a nM
Citation
 Squarcialupi, L; Catarzi, D; Varano, F; Betti, M; Falsini, M; Vincenzi, F; Ravani, A; Ciancetta, A; Varani, K; Moro, S; Colotta, V Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor. Eur J Med Chem 108:117-33 (2016) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50138715
Synonyms:
CHEMBL3753642
Type:
Small organic molecule
Emp. Form.:
C21H14N6OS
Mol. Mass.:
398.44
SMILES:
O=C(Nc1nc(nc2cn(nc12)-c1ccccc1)-c1cccs1)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: