Reaction Details Report a problem with these data
Target
L-lactate dehydrogenase B chain
Ligand
BDBM50031638
Substrate
n/a
Meas. Tech.
ChEMBL_1555231 (CHEMBL3768757)
Ki
92000±n/a nM
Citation
 Rani, R; Kumar, V Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy. J Med Chem 59:487-96 (2016) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase B chain
Synonyms:
L-lactate dehydrogenase B | L-lactate dehydrogenase B chain | LDH heart subunit | LDH-B | LDH-H | LDHB | LDHB_HUMAN | Lactate dehydrogenase B (LDHB) | Renal carcinoma antigen NY-REN-46
Type:
Oxidoreductase; homotetramer
Mol. Mass.:
36635.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
334
Sequence:
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
  
Inhibitor
Name:
BDBM50031638
Synonyms:
2,3-Dihydroxy-4-isopropyl-6-methyl-naphthalene-1-carboxylic acid | CHEMBL310405
Type:
Small organic molecule
Emp. Form.:
C15H16O4
Mol. Mass.:
260.2851
SMILES:
CC(C)c1c(O)c(O)c(C(O)=O)c2ccc(C)cc12
Structure:
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