Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50139655
Substrate
n/a
Meas. Tech.
ChEBML_1553863
Ki
1.3±n/a nM
Citation
 Zhou, G; Aslanian, R; Gallo, G; Khan, T; Kuang, R; Purakkattle, B; De Ruiz, M; Stamford, A; Ting, P; Wu, H; Wang, H; Xiao, D; Yu, T; Zhang, Y; Mullins, D; Hodgson, R Discovery of aminoquinazoline derivatives as human A(2A) adenosine receptor antagonists. Bioorg Med Chem Lett 26:1348-54 (2016) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_RAT | ADENOSINE A2a | Adenosine A2 receptor | Adenosine A2a receptor (A2a) | Adenosine Receptors A2a (A2a) | Adenosine receptor A2a and A3 | Adenosine receptors A2a | Adora2a | Rat striatal adenosine A2a receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45015.65
Organism:
Rattus norvegicus (rat)
Description:
Rat A2A receptors expressed in CHO cells.
Residue:
410
Sequence:
MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
  
Inhibitor
Name:
BDBM50139655
Synonyms:
CHEMBL3764083
Type:
Small organic molecule
Emp. Form.:
C19H14FN5O
Mol. Mass.:
347.3458
SMILES:
Nc1nc(C(=O)NCc2cccc3cccnc23)c2cccc(F)c2n1
Structure:
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