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Target
Kinesin-like protein KIF20A
Ligand
BDBM50140927
Substrate
n/a
Meas. Tech.
ChEMBL_1548834 (CHEMBL3755390)
IC50
3600±n/a nM
Citation
 Labrière, C; Talapatra, SK; Thoret, S; Bougeret, C; Kozielski, F; Guillou, C New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations. Bioorg Med Chem 24:721-34 (2016) [PubMed]  Article 
Target
Name:
Kinesin-like protein KIF20A
Synonyms:
GG10_2 | KI20A_HUMAN | KIF20A | Kinesin-like protein KIF20A | MKLP2 | MKLP2 | Mitotic kinesin-like protein 2 | RAB6KIFL | Rab6-interacting kinesin-like protein | Rabkinesin-6
Type:
PROTEIN
Mol. Mass.:
100281.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104520
Residue:
890
Sequence:
MSQGILSPPAGLLSDDDVVVSPMFESTAADLGSVVRKNLLSDCSVVSTSLEDKQQVPSEDSMEKVKVYLRVRPLLPSELERQEDQGCVRIENVETLVLQAPKDSFALKSNERGIGQATHRFTFSQIFGPEVGQASFFNLTVKEMVKDVLKGQNWLIYTYGVTNSGKTHTIQGTIKDGGILPRSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEMKKLSLLNGGLQEEELSTSLKRSVYIESRIGTSTSFDSGIAGLSSISQCTSSSQLDETSHRWAQPDTAPLPVPANIRFSIWISFFEIYNELLYDLLEPPSQQRKRQTLRLCEDQNGNPYVKDLNWIHVQDAEEAWKLLKVGRKNQSFASTHLNQNSSRSHSIFSIRILHLQGEGDIVPKISELSLCDLAGSERCKDQKSGERLKEAGNINTSLHTLGRCIAALRQNQQNRSKQNLVPFRDSKLTRVFQGFFTGRGRSCMIVNVNPCASTYDETLHVAKFSAIASQLVHAPPMQLGFPSLHSFIKEHSLQVSPSLEKGAKADTGLDDDIENEADISMYGKEELLQVVEAMKTLLLKERQEKLQLEMHLRDEICNEMVEQMQQREQWCSEHLDTQKELLEEMYEEKLNILKESLTSFYQEEIQERDEKIEELEALLQEARQQSVAHQQSGSELALRRSQRLAASASTQQLQEVKAKLQQCKAELNSTTEELHKYQKMLEPPPSAKPFTIDVDKKLEEGQKNIRLLRTELQKLGESLQSAERACCHSTGAGKLRQALTTCDDILIKQDQTLAELQNNMVLVKLDLRKKAACIAEQYHTVLKLQGQVSAKKRLGTNQENQQPNQQPPGKKPFLRNLLPRTPTCQSSTDCSPYARILRSRRSPLLKSGPFGKKY
  
Inhibitor
Name:
BDBM50140927
Synonyms:
CHEMBL3752100
Type:
Small organic molecule
Emp. Form.:
C19H16N2O2
Mol. Mass.:
304.3425
SMILES:
COc1cc(OC)cc(\C=C(/C#N)c2c[nH]c3ccccc23)c1
Structure:
Search PDB for entries with ligand similarity: