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TargetGRIA3
LigandBDBM50142614
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1552620
Ki 6880±n/a nM
Citation Szymanska, EFrydenvang, KPickering, DSKrintel, CNielsen, BKooshki, AZachariassen, LGOlsen, LKastrup, JSJohansen, TN Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. J Med Chem59:448-61 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
GRIA3
Name:GRIA3
Synonyms:Glutamate receptor 3 | Glutamate receptor ionotropic, AMPA 3 | Glutamate-AMPA
Type:Enzyme Catalytic Domain
Mol. Mass.:100383.57
Organism:RAT
Description:Glutamate-AMPA GRIA3 RAT::P19492
Residue:888
Sequence:
MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTE
KPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVT
PSFPTDADVQFVIQMRPALKGAILSLLSYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNW
QVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYM
LANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYT
SALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGM
TGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIV
VTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPE
TKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS
FLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIF
NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE
SAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVR
KSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLN
EQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEF
CYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50142614
NameBDBM50142614
Synonyms:CHEMBL3758336
TypeSmall organic molecule
Emp. Form.C14H12Cl2N2O3
Mol. Mass.327.163
SMILESN[C@@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a