Target
Carbonic anhydrase 12
Ligand
BDBM50143979
Substrate
n/a
Meas. Tech.
ChEMBL_1551383 (CHEMBL3762504)
Ki
4.4±n/a nM
Citation
 Carradori, SSecci, DDe Monte, CMollica, ACeruso, MAkdemir, ASobolev, APCodispoti, RDe Cosmi, FGuglielmi, PSupuran, CT A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms. Bioorg Med Chem 24:1095-105 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50143979
Synonyms:
CHEMBL3759331
Type:
Small organic molecule
Emp. Form.:
C14H10ClNO3S
Mol. Mass.:
307.752
SMILES:
Clc1ccc(CN2C(=O)c3ccccc3S2(=O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: