Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50143907
Substrate
n/a
Meas. Tech.
ChEMBL_1551381 (CHEMBL3762502)
Ki
>10000±n/a nM
Citation
 Carradori, S; Secci, D; De Monte, C; Mollica, A; Ceruso, M; Akdemir, A; Sobolev, AP; Codispoti, R; De Cosmi, F; Guglielmi, P; Supuran, CT A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms. Bioorg Med Chem 24:1095-105 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50143907
Synonyms:
CHEMBL3759629
Type:
Small organic molecule
Emp. Form.:
C15H10F3NO3S
Mol. Mass.:
341.305
SMILES:
FC(F)(F)c1cccc(CN2C(=O)c3ccccc3S2(=O)=O)c1
Structure:
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