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Target
Carbonic anhydrase 12
Ligand
BDBM50334349
Substrate
n/a
Meas. Tech.
ChEMBL_1551387 (CHEMBL3762508)
Ki
5.7±n/a nM
Citation
 Lomelino, CL; Mahon, BP; McKenna, R; Carta, F; Supuran, CT Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111. Bioorg Med Chem 24:976-81 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50334349
Synonyms:
4-(3-(3-nitrophenyl)ureido)benzenesulfonamide | 4-{[(3'-Nitrophenyl)carbamoyl]amino}benzenesulfonamide | 4-{[(3-nitrophenyl)carbamoyl]amino}benzenesulfonamide | CA IX inhibitor, (C)1 | CHEMBL1614844
Type:
Small organic molecule
Emp. Form.:
C13H12N4O5S
Mol. Mass.:
336.323
SMILES:
NS(=O)(=O)c1ccc(NC(=O)Nc2cccc(c2)[N+]([O-])=O)cc1
Structure:
Search PDB for entries with ligand similarity: