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Target
Interleukin-6 receptor subunit beta
Ligand
BDBM50145196
Substrate
n/a
Meas. Tech.
ChEMBL_1555122 (CHEMBL3768044)
IC50
>100000±n/a nM
Citation
 Singh, S; Gajulapati, V; Gajulapati, K; Goo, JI; Park, YH; Jung, HY; Lee, SY; Choi, JH; Kim, YK; Lee, K; Heo, TH; Choi, Y Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers. Bioorg Med Chem Lett 26:1282-6 (2016) [PubMed]  Article 
Target
Name:
Interleukin-6 receptor subunit beta
Synonyms:
CD_antigen=CD130 | CDw130 | IL-6 receptor subunit beta | IL-6R subunit beta | IL-6R-beta | IL-6RB | IL6RB_HUMAN | IL6ST | Interleukin-6 receptor subunit beta | Interleukin-6 signal transducer | Membrane glycoprotein 130 | Oncostatin-M receptor subunit alpha | gp130
Type:
PROTEIN
Mol. Mass.:
103525.80
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108130
Residue:
918
Sequence:
MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEGMPKSYLPQTVRQGGYMPQ
  
Inhibitor
Name:
BDBM50145196
Synonyms:
CHEMBL3765446
Type:
Small organic molecule
Emp. Form.:
C13H21NO4
Mol. Mass.:
255.3101
SMILES:
CC(C)[C@H]1COC(=O)N1C(=O)[C@@H](C)[C@H](O)C(C)=C |r|
Structure:
Search PDB for entries with ligand similarity: