Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM50145652
Substrate
n/a
Meas. Tech.
ChEMBL_1556269 (CHEMBL3769268)
IC50
2266±n/a nM
Citation
 Goldberg, DRDe Lombaert, SAiello, RBourassa, PBarucci, NZhang, QParalkar, VValentine, JZavadoski, W Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett 26:1124-9 (2016) [PubMed]  Article 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
  
Inhibitor
Name:
BDBM50145652
Synonyms:
CHEMBL3763909
Type:
Small organic molecule
Emp. Form.:
C24H26ClF3N8O3
Mol. Mass.:
566.963
SMILES:
Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1nc(N)nc(n1)N1CCC2(CNC(C2)C(O)=O)CC1)C(F)(F)F |r|
Structure:
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