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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50146461
Substrate
n/a
Meas. Tech.
ChEMBL_1555055 (CHEMBL3767633)
IC50
134±n/a nM
Citation
 Malachowski, WP; Winters, M; DuHadaway, JB; Lewis-Ballester, A; Badir, S; Wai, J; Rahman, M; Sheikh, E; LaLonde, JM; Yeh, SR; Prendergast, GC; Muller, AJ O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. Eur J Med Chem 108:564-76 (2016) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50146461
Synonyms:
CHEMBL3765807
Type:
Small organic molecule
Emp. Form.:
C7H9Cl2NO
Mol. Mass.:
194.058
SMILES:
Cl.NOCc1cccc(Cl)c1
Structure:
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