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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50179280
Substrate
n/a
Meas. Tech.
ChEMBL_1555070 (CHEMBL3767816)
IC50
16±n/a nM
Citation
 Abate, C; Riganti, C; Pati, ML; Ghigo, D; Berardi, F; Mavlyutov, T; Guo, LW; Ruoho, A Development of sigma-1 (s1) receptor fluorescent ligands as versatile tools to studys1 receptors. Eur J Med Chem 108:577-85 (2016) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50179280
Synonyms:
1-(4-(6-methoxynaphthalen-1-yl)butyl)-4-methylpiperidine | CHEMBL176941 | CHEMBL545278
Type:
Small organic molecule
Emp. Form.:
C21H29NO
Mol. Mass.:
311.4611
SMILES:
COc1ccc2c(CCCCN3CCC(C)CC3)cccc2c1
Structure:
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