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TargetProtein cereblon
LigandBDBM50070114
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1555520
Ki 22700±n/a nM
Citation Boichenko, IDeiss, SBär, KHartmann, MDHernandez Alvarez, B A FRET-Based Assay for the Identification and Characterization of Cereblon Ligands. J Med Chem59:770-4 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein cereblon
Name:Protein cereblon
Synonyms:CRBN | Protein cereblon
Type:PROTEIN
Mol. Mass.:50537.73
Organism:Homo sapiens (Human)
Description:ChEMBL_116917
Residue:442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
ALLPTIPDTEDEISPDKVILCL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50070114
NameBDBM50070114
Synonyms:(+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-isoindole-1,3-dione | 2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | CHEMBL468 | K-17 | THALIDOMIDE | Thalomid | [(R,S)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
TypeSmall organic molecule
Emp. Form.C13H10N2O4
Mol. Mass.258.2295
SMILESO=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a