Reaction Details Report a problem with these data
Target
Carbonic anhydrase 12
Ligand
BDBM50146602
Substrate
n/a
Meas. Tech.
ChEMBL_1555759 (CHEMBL3766370)
Ki
4.3±n/a nM
Citation
 Cornelio, B; Laronze-Cochard, M; Ceruso, M; Ferraroni, M; Rance, GA; Carta, F; Khlobystov, AN; Fontana, A; Supuran, CT; Sapi, J 4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies. J Med Chem 59:721-32 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50146602
Synonyms:
CHEMBL3763967
Type:
Small organic molecule
Emp. Form.:
C12H12N2O2S
Mol. Mass.:
248.301
SMILES:
Nc1cccc(c1)-c1ccc(cc1)S(N)(=O)=O
Structure:
Search PDB for entries with ligand similarity: