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Target
Histone deacetylase 8
Ligand
BDBM50148614
Substrate
n/a
Meas. Tech.
ChEMBL_1556879 (CHEMBL3771761)
IC50
2700±n/a nM
Citation
 Senger, J; Melesina, J; Marek, M; Romier, C; Oehme, I; Witt, O; Sippl, W; Jung, M Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors. J Med Chem 59:1545-55 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50148614
Synonyms:
CHEMBL3770136
Type:
Small organic molecule
Emp. Form.:
C17H14N2O3
Mol. Mass.:
294.3047
SMILES:
ONC(=O)c1coc(n1)C(c1ccccc1)c1ccccc1
Structure:
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